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| Macêdo,D.S.; Araújo,D.P.; Sampaio,L.R.L.; Vasconcelos,S.M.M.; Sales,P.M.G.; Sousa,F.C.F.; Hallak,J.E.; Crippa,J.A.; Carvalho,A.F.. |
| Prenatal immune challenge (PIC) in pregnant rodents produces offspring with abnormalities in behavior, histology, and gene expression that are reminiscent of schizophrenia and autism. Based on this, the goal of this article was to review the main contributions of PIC models, especially the one using the viral-mimetic particle polyriboinosinic-polyribocytidylic acid (poly-I:C), to the understanding of the etiology, biological basis and treatment of schizophrenia. This systematic review consisted of a search of available web databases (PubMed, SciELO, LILACS, PsycINFO, and ISI Web of Knowledge) for original studies published in the last 10 years (May 2001 to October 2011) concerning animal models of PIC, focusing on those using poly-I:C. The results showed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Schizophrenia; Animal models; Neurodevelopment; Prenatal immune activation; Poly-I:C. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300001 |
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